Antacid Compounds
Lattice layered compounds

Magaldrate
Al5Mg10(OH)31(SO4)2 · x H2O

Magaldrate is a lattice layered, crystalline complex of magnesium aluminium hydroxysulphate. It has an exceptionally rapid reaction rate with gastric acid whilst maintaining the stomach pH in the optimum range of 3 - 5. The reaction rate is unaffected by the presence of proteins and pepsin. Magaldrate can adsorb large quantities of bile acids, preventing these aggressors from attacking the mucous membranes.

Magaldrate Powder C 410 / C 411

C410 / C411 are spray dried powders consisting of agglomerations of very fine primary crystals. These agglomerations are mainly spherical in nature, ensuring excellent flow characteristics.
These powder grades are found in the majority of magaldrate tablets in the market today.

Type  Assay Al(OH)3
 (200°C/4h)
 Assay Mg(OH)2
 (200°C/4h)
 Density (tapped)  d50 Pharmacopoeia  
C410  32,1 - 45,9 [%]  49,2 - 66,6 [%]  0,4 - 0,6 [g/ml] 15 - 30 µm PhEur, USP
C411  32,1 - 45,9 [%]  49,2 - 66,6 [%]  0,6 - 0,8 [g/ml] 20 - 35 µm PhEur, USP

Magaldrate Powder C 425

C425 is a milled magaldrate powder, ideal for the formulation of soft tablets and candies as well as for powder mixtures intended for resuspension, for example, powder sachets.
It is also possible to resuspend C425 for liquid formulations depending on process conditions and formulation requirements.

Type  Assay Al(OH)3
 
(200°C/4h)
 Assay Mg(OH)2
 (200°C/4h)
 Density (tapped)  d50 Pharmacopoeia  
C425  32,1 - 45,9 [%]  49,2 - 66,6 [%]  0,4 - 0,6 [g/ml] 5 - 10 µm  PhEurUSP

Magaldrate Suspension C 632

C 632 is a viscous paste with a magaldrate content of 20 – 25 %. The viscosity borders on the limit of flow capability. The paste is stable on storage and after transportation, displaying only slight sedimentation and no caking. C 632 is suitable for the production of both single and double strength formulations.

Other concentrations of C632 are available on demand.

Type  Assay Al(OH)3
 (200°C/4h)
 Assay Mg  (OH)2
 (200°C/4h)
 Viscosity
 (Brookfield)
 d50 Pharmacopoeia  
C632 32,1 - 45,9 [%] 49,2 - 66,6 [%] max. 400 mPa s
(LV 3/12)
6 - 10 µm  USP

Hydrotalcite
Al2Mg6(OH)16CO3 · x H2O

Hydrotalcite is a lattice layered, crystalline complex of magnesium aluminium hydroxycarbonate. It contains a higher proportion of magnesium than magaldrate. Hydrotalcite reacts rapidly with gastric acid even in the presence of pepsin and proteins.

Hydrotalcite Powder C 300

C 300 is a spray dried powder for use in all tablet formulations, preferably after pre-granulation.
A milled quality is available on request which is suitable for the formulation of soft tablets and candies or for resuspending for liquid formulations.

Type Assay Al2O3  Assay MgO  Density (tapped)  d50 Pharmacopoeia  
C300 15,3 - 18,7 [%]  36,0 - 44,0 [%]  0,4 - 0,6 [g/ml]  10 - 30 µm  BP

Hydrotalcite Suspension C 600

C 600 has a hydrotalcite content of 14 – 20 %. It is ideal for use in liquid formulations giving excellent mouth-feel and stability compared to formulations containing resuspended hydrotalcite powders.

Type  Assay Al2O3  Assay MgO Pharmacopoeia
C600  2,5 - 3,5 [%]  6,0 - 7,8 [%]  (BP)

Almagate
Al2Mg6(OH)14(CO3)2 · x H2O

Almagate is a crystalline compound similar to hydrotalcite. It reacts very rapidly with gastric acid even in the presence of pepsin and proteins.

Almagate Powder C 310

C310 is a spray dried powder with similar properties to hydrotalcite powder. It is suitable for the production of fast acting tablets.

Almagate Suspension C 610

C610 has an almagate content of ca. 16%. It is ideal for use in liquid antacid formulations.

 
© Copyright SRL Pharma 2017